Intratumor heterogeneity of members of the monocarboxylate transporter (MCT/SLC16) and organic cation transporter (OCT/SLC22) family in clear cell renal cell carcinoma (ccRCC)
10 project-relevant publications [ICEPHA PI(s) and PhD student(s) in bold letters]
- Brech D, Herbstritt AS, Diederich S, Straub T, Kokolakis E, Irmler M, Beckers J, Buttner FA, Schaeffeler E, Winter S, Schwab M, Nelson PJ, Noessner E. 2022. Dendritic Cells or Macrophages? The Microenvironment of Human Clear Cell Renal Cell Carcinoma Imprints a Mosaic Myeloid Subtype Associated with Patient Survival. Cells 11:doi:10.3390/cells11203289
- Buttner FA, Winter S, Stuhler V, Rausch S, Hennenlotter J, Fussel S, Zastrow S, Meinhardt M, Toma M, Jeronimo C, Henrique R, Miranda-Goncalves V, Kroger N, Ribback S, Hartmann A, Agaimy A, Stohr C, Polifka I, Fend F, Scharpf M, Comperat E, Wasinger G, Moch H, Stenzl A, Gerlinger M, Bedke J, Schwab M, Schaeffeler E. 2022. A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy. Genome Med 14:105. doi:10.1186/s13073-022-01105-y
- Gurgen D, Becker M, Dahlmann M, Flechsig S, Schaeffeler E, Buttner FA, Schmees C, Bohnert R, Bedke J, Schwab M, Wendler JJ, Schostak M, Jandrig B, Walther W, Hoffmann J. 2022. A Molecularly Characterized Preclinical Platform of Subcutaneous Renal Cell Carcinoma (RCC) Patient-Derived Xenograft Models to Evaluate Novel Treatment Strategies. Front Oncol 12:889789. doi:10.3389/fonc.2022.889789
- Kandabarau S, Leiz J, Krohn K, Winter S, Bedke J, Schwab M, Schaeffeler E, Edemir B. 2019. Hypertonicity-Affected Genes Are Differentially Expressed in Clear Cell Renal Cell Carcinoma and Correlate with Cancer-Specific Survival. Cancers (Basel) 12:doi:10.3390/cancers12010006
- Neef SK, Winter S, Hofmann U, Murdter TE, Schaeffeler E, Horn H, Buck A, Walch A, Hennenlotter J, Ott G, Fend F, Bedke J, Schwab M, Haag M. 2020. Optimized protocol for metabolomic and lipidomic profiling in formalin-fixed paraffin-embedded kidney tissue by LC-MS. Anal Chim Acta 1134:125-35. doi:10.1016/j.aca.2020.08.005
- Reustle A, Di Marco M, Meyerhoff C, Nelde A, Walz JS, Winter S, Kandabarau S, Buttner F, Haag M, Backert L, Kowalewski DJ, Rausch S, Hennenlotter J, Stuhler V, Scharpf M, Fend F, Stenzl A, Rammensee HG, Bedke J, Stevanovic S, Schwab M, Schaeffeler E. 2020. Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy. Genome Med 12:32. doi:10.1186/s13073-020-00731-8
- Sauter-Meyerhoff C, Bohnert R, Mazzola P, Stuhler V, Kandabarau S, Buttner FA, Winter S, Herrmann L, Rausch S, Hennenlotter J, Fend F, Scharpf M, Stenzl A, Ossowski S, Bedke J, Schwab M, Schaeffeler E. 2021. Characterization of Genetic Heterogeneity in Recurrent Metastases of Renal Cell Carcinoma. Cancers (Basel) 13:doi:10.3390/cancers13246221
- Stanulla M, Schaeffeler E, Moricke A, Buchmann S, Zimmermann M, Igel S, Schmiegelow K, Flotho C, Hartmann H, Illsinger S, Sauerbrey A, Junk SV, Schutte P, Hinze L, Lauten M, Modlich S, Kolb R, Rossig C, Schwabe G, Gnekow AK, Fleischhack G, Schlegel PG, Schunemann HJ, Kratz CP, Cario G, Schrappe M, Schwab M. 2021. Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia. Leukemia 35:2650-7. doi:10.1038/s41375-021-01203-7
- Stuhler V, Herrmann L, Rausch S, Stenzl A, Bedke J. 2022. Real world data on IO-based therapy for metastatic renal cell carcinoma. J Cancer Res Clin Oncol 10.1007/s00432-022-04173-0:doi:10.1007/s00432-022-04173-0
- Zhou Y, Tremmel R, Schaeffeler E, Schwab M, Lauschke VM. 2022. Challenges and opportunities associated with rare-variant pharmacogenomics. Trends Pharmacol Sci 43:852-65. doi:10.1016/j.tips.2022.07.002