Home » Graduate Program (2018-2022) » Publications » Project 3

The role of potassium channels and their gene variants for hormone-dependent breast cancer progression and endocrine treatment outcome

10 project-relevant publications [ICEPHA PI(s) and PhD student(s) in bold letters] 

  1. Bachmann M, Rossa A, Varanita T, Fioretti B, Biasutto L, Milenkovic S, Checchetto V, Peruzzo R, Ahmad SA, Patel SH, Lukowski R, Edwards MJ, Ceccarelli M, Gulbins E, Zoratti M, Mattarei A, Szabo I. 2022. Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivo. Cell Death Dis 13:1055. doi:10.1038/s41419-022-05463-8
  2. Bischof H, Burgstaller S, Springer A, Matt L, Rauter T, Bachkonig OA, Schmidt T, Groschner K, Schindl R, Madl T, Plesnila N, Lukowski R Graier WF, Malli R. 2021. Potassium ions promote hexokinase-II dependent glycolysis. iScience 24:102346. doi:10.1016/j.isci.2021.102346
  3. Burgstaller S, Bischof H, Matt L, Lukowski R. 2022a. Assessing K(+) ions and K(+) channel functions in cancer cell metabolism using fluorescent biosensors. Free Radic Biol Med 181:43-51. doi:10.1016/j.freeradbiomed.2022.01.026
  4. Burgstaller S, Bischof H, Rauter T, Schmidt T, Schindl R, Patz S, Groschup B, Filser S, van den Boom L, Sasse P, Lukowski R, Plesnila N, Graier WF, Malli R. 2021. Immobilization of Recombinant Fluorescent Biosensors Permits Imaging of Extracellular Ion Signals. ACS Sens 6:3994-4000. doi:10.1021/acssensors.1c01369
  5. Burgstaller S, Wagner TR, Bischof H, Bueckle S, Padamsey A, Frecot D, Kaiser PD, Skrabak D, Malli R, Lukowski R*, Rothbauer U*. 2022b. Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors. iScience 25:104907. doi:10.1016/j.isci.2022.104907. *equal contribution
  6. Gross D, Bischof H, Maier S, Sporbeck K, Birkenfeld AL, Malli R, Ruth P, Proikas-Cezanne T, Lukowski R. 2022. IK(Ca) channels control breast cancer metabolism including AMPK-driven autophagy. Cell Death Dis 13:902. doi:10.1038/s41419-022-05329-z
  7. Khor CC, Winter S, Sutiman N, Murdter TE, Chen S, Lim JSL, Li Z, Li J, Sim KS, Ganchev B, Eccles D, Eccles B, Tapper W, Zgheib NK, Tfayli A, Ng RCH, Yap YS, Lim E, Wong M, Wong NS, Ang PCS, Dent R, Tremmel R, Klein K, Schaeffeler E, Zhou Y, Lauschke VM, Eichelbaum M, Schwab M, Brauch HB, Chowbay B, Schroth W. 2023. Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations. Clin Pharmacol Ther 113:712-23. doi:10.1002/cpt.2846
  8. Mohr CJ, Gross D, Sezgin EC, Steudel FA, Ruth P, Huber SM, Lukowski R. 2019. K(Ca)3.1 Channels Confer Radioresistance to Breast Cancer Cells. Cancers (Basel) 11:doi:10.3390/cancers11091285
  9. Mohr CJ, Schroth W, Murdter TE, Gross D, Maier S, Stegen B, Dragoi A, Steudel FA, Stehling S, Hoppe R, Madden S, Ruth P, Huber SM, Brauch H, Lukowski R. 2022. Subunits of BK channels promote breast cancer development and modulate responses to endocrine treatment in preclinical models. Br J Pharmacol 179:2906-24. doi:10.1111/bph.15147
  10. Schroth W, Buttner FA, Kandabarau S, Hoppe R, Fritz P, Kumbrink J, Kirchner T, Brauer HA, Ren Y, Henderson D, Madden SF, Sauer G, Fehm T, Wallwiener D, Fasching PA, Murdter T, Schwab M, Brauch H, German T, Group AIC. 2020. Gene Expression Signatures of BRCAness and Tumor Inflammation Define Subgroups of Early-Stage Hormone Receptor-Positive Breast Cancer Patients. Clin Cancer Res 26:6523-34. doi:10.1158/1078-0432.CCR-20-1923