Home » Graduate Program (2018-2022) » Publications » Project 1

The model of the fruit fly Drosophila melanogaster as a novel and highly innovative test system for human membrane transporters in anti-cancer drug development

10 project-relevant publications [ICEPHA PI(s) and PhD student(s) in bold letters] 

  1. Chen M, Neul C, Schaeffeler E, Frisch F, Winter S, Schwab M, Koepsell H, Hu S, Laufer S, Baker SD, Sparreboom A, Nies AT. 2020. Sorafenib Activity and Disposition in Liver Cancer Does Not Depend on Organic Cation Transporter 1. Clin Pharmacol Ther 107:227-37. doi:10.1002/cpt.1588
  2. Huang KM, Zavorka Thomas M, Magdy T, Eisenmann ED, Uddin ME, DiGiacomo DF, Pan A, Keiser M, Otter M, Xia SH, Li Y, Jin Y, Fu Q, Gibson AA, Bonilla IM, Carnes CA, Corps KN, Coppola V, Smith SA, Addison D, Nies AT, Bundschuh R, Chen T, Lustberg MB, Wang J, Oswald S, Campbell MJ, Yan PS, Baker SD, Hu S, Burridge PW, Sparreboom A. 2021. Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Proc Natl Acad Sci U S A 118:doi:10.1073/pnas.2020168118
  3. Ma R, Haji-Ghassemi O, Ma D, Jiang H, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z. 2020. Structural basis for diamide modulation of ryanodine receptor. Nat Chem Biol 16:1246-54. doi:10.1038/s41589-020-0627-5
  4. Neul C, Hofmann U, Schaeffeler E, Winter S, Klein K, Giacomini KM, Eichelbaum M, Schwab M, Nies AT. 2021. Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins. Br J Pharmacol 178:1459-74. doi:10.1111/bph.15370
  5. Nies AT, Konig J, Hofmann U, Kolz C, Fromm MF, Schwab M. 2021. Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters. Pharmaceutics 13:doi:10.3390/pharmaceutics13030369
  6. Nies AT, Schaeffeler E, Schwab M. 2022. Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation. Pharmacol Ther 238:108268. doi:10.1016/j.pharmthera.2022.108268
  7. Tremmel R, Nies AT, van Eijck BAC, Handin N, Haag M, Winter S, Buttner FA, Kolz C, Klein F, Mazzola P, Hofmann U, Klein K, Hoffmann P, Nothen MM, Gaugaz FZ, Artursson P, Schwab M, Schaeffeler E. 2022. Hepatic Expression of the Na(+)-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation. Int J Mol Sci 23:doi:10.3390/ijms23137468
  8. Unger MS, Mudunuru J, Schwab M, Hopf C, Drewes G, Nies AT, Zamek-Gliszczynski MJ, Reinhard FBM. 2020a. Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space. Mol Pharm 17:488-98. doi:10.1021/acs.molpharmaceut.9b00897
  9. Unger MS, Schumacher L, Enzlein T, Weigt D, Zamek-Gliszczynski MJ, Schwab M, Nies AT, Drewes G, Schulz S, Reinhard FBM, Hopf C. 2020b. Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs. Anal Chem 92:11851-9. doi:10.1021/acs.analchem.0c02186
  10. Zuber R, Shaik KS, Meyer F, Ho HN, Speidel A, Gehring N, Bartoszewski S, Schwarz H, Moussian B. 2019. The putative C-type lectin Schlaff ensures epidermal barrier compactness in Drosophila. Sci Rep 9:5374. doi:10.1038/s41598-019-41734-9