Home » Graduate Program (2018-2022) » Publications » Project 6

Establishment of Stable lsotope-resolved in vivo Metabolomics as Test System to assess Membrane-associated Drug Targets in Cancer

10 project-relevant publications [ICEPHA PI(s) and PhD student(s) in bold letters] 

  1. Cho MS, Li J, Gonzalez-Delgado R, Lee H, Vasquez M, He T, He Y, Liu K, Sasano T, Nurnberg B, Sood AK, Wong STC, Afshar-Kharghan V. 2021. The effect of platelet G proteins on platelet extravasation and tumor growth in the murine model of ovarian cancer. Blood Adv 5:1947-51. doi:10.1182/bloodadvances.2020003410
  2. Granja TF, Köhler D, Leiss V, Eggstein C, Nürnberg B, Rosenberger P, Beer-Hammer S. Platelets and the Cybernetic Regulation of Ischemic Inflammatory Responses through PNC Formation Regulated by Extracellular Nucleotide Metabolism and Signaling. Cells. 2022 Sep 27;11(19):3009. doi: 10.3390/cells11193009.
  3. Lackner M, Neef SK, Winter S, Beer-Hammer S, Nurnberg B, Schwab M, Hofmann U, Haag M. 2022. Untargeted stable isotope-resolved metabolomics to assess the effect of PI3Kbeta inhibition on metabolic pathway activities in a PTEN null breast cancer cell line. Front Mol Biosci 9:1004602. doi:10.3389/fmolb.2022.1004602
  4. Leiss V, Reisinger E, Speidel A, Beer-Hammer S, Nurnberg B. 2021. Analyses of Gnai3-iresGFP reporter mice reveal unknown Galpha(i3) expression sites. Sci Rep 11:14271. doi:10.1038/s41598-021-93591-0
  5. Leiss V, Schonsiegel A, Gnad T, Kerner J, Kaur J, Sartorius T, Machann J, Schick F, Birnbaumer L, Haring HU, Pfeifer A, Nurnberg B. 2020. Lack of Galpha(i2) proteins in adipocytes attenuates diet-induced obesity. Mol Metab 40:101029. doi:10.1016/j.molmet.2020.101029
  6. Leuthold P, Schwab M, Hofmann U, Winter S, Rausch S, Pollak MN, Hennenlotter J, Bedke J, Schaeffeler E, Haag M. 2018. Simultaneous Extraction of RNA and Metabolites from Single Kidney Tissue Specimens for Combined Transcriptomic and Metabolomic Profiling. J Proteome Res 17:3039-49. doi:10.1021/acs.jproteome.8b00199
  7. Montes-Mojarro IA, Steinhilber J, Griessinger CM, Rau A, Gersmann AK, Kohlhofer U, Fallier-Becker P, Liang HC, Hofmann U, Haag M, Klapper W, Schaeffeler E, Pichler BJ, Schwab M, Fend F, Bonzheim I, Quintanilla-Martinez L. 2022. CD147 a direct target of miR-146a supports energy metabolism and promotes tumor growth in ALK+ ALCL. Leukemia 36:2050-63. doi:10.1038/s41375-022-01617-x
  8. Neef SK, Janssen N, Winter S, Wallisch SK, Hofmann U, Dahlke MH, Schwab M, Murdter TE, Haag M. 2020. Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS. Metabolites 10:doi:10.3390/metabo10120494
  9. Nurnberg B, Beer-Hammer S. 2019. Function, Regulation and Biological Roles of PI3Kgamma Variants. Biomolecules 9:doi:10.3390/biom9090427
  10. Reustle A, Menig LS, Leuthold P, Hofmann U, Stuhler V, Schmees C, Becker M, Haag M, Klumpp V, Winter S, Buttner FA, Rausch S, Hennenlotter J, Fend F, Scharpf M, Stenzl A, Bedke J, Schwab M, Schaeffeler E. 2022. Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma. Clin Transl Med 12:e883. doi:10.1002/ctm2.883