Doctoral project (P2):

Validation of xenosensing nuclear receptor PXR as a therapeutic target in cancer chemotherapy

Further reading:

[1] Rashidian A, Mustonen EK, Kronenberger T, Schwab M, Burk O, Laufer SA, Pantsar T. Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist. Comput Struct Biotechnol J. 2022 Jun 13;20:3004-3018. doi: 10.1016/j.csbj.2022.06.020. 

[2] Mustonen EK, Pantsar T, Rashidian A, Reiner J, Schwab M, Laufer S, Burk O. Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library. Cells. 2022 Apr 12;11(8):1299. doi: 10.3390/cells11081299.

[3] Mustonen EK, Lee SML, Nieß H, Schwab M, Pantsar T, Burk O. Identification and characterization of novel splice variants of human farnesoid X receptor. Arch Biochem Biophys. 2021 Jul 15;705:108893. doi: 10.1016/j.abb.2021.108893.

Awards & prices:

N.N.