Home » Graduate Program (2014-2017) » Publications

Original work of the PhD students during the first funding period (2014-2017)

(ICEPHA funded PhD students in bold)

1)     Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor. Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O. Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013.

2)     Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B. Arch Toxicol 2018, accepted DOI: 10.1007/s00204-018-2165-4

3)     Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor. Jeske J, Windshügel B, Thasler WE, Schwab M, Burk O. Arch Toxicol. 2017 Jun;91(6):2375-2390. doi: 10.1007/s00204-017-1948-3.

4)     MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation. Schmitt A, Grondona P, Maier T, Brändle M, Schönfeld C, Jäger G, Kosnopfel C, Eberle FC, Schittek B, Schulze-Osthoff K, Yazdi AS, Hailfinger S. J Invest Dermatol. 2016 Apr;136(4):788-97. doi: 10.1016/j.jid.2015.12.027.

5)     TRPM8 is required for survival and radioresistance of glioblastoma cells. Klumpp D, Frank SC, Klumpp L, Sezgin EC, Eckert M, Edalat L, Bastmeyer M, Zips D, Ruth P, Huber SM. Oncotarget. 2017 Sep 30;8(56):95896-95913. doi: 10.18632/oncotarget.21436.

6)     Cellular Effects of the Antiepileptic Drug Valproic Acid in Glioblastoma. Eckert M, Klumpp L, Huber S. Cell Physiol Biochem. 2017;44(4):1591-1605. doi: 10.1159/000485753.

7)     KCa3.1 channels and glioblastoma: in vitro studies. Klumpp L, Sezgin EC, Skardelly M, Eckert F, Huber SM. Curr Neuropharmacol. 2017 Aug 8. doi: 10.2174/1570159X15666170808115821.

8)     BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells. Edalat L, Stegen B, Klumpp L, Haehl E, Schilbach K, Lukowski R, Kühnle M, Bernhardt G, Buschauer A, Zips D, Ruth P, Huber SM. Oncotarget. 2016 Mar 22;7(12):14259-78. doi: 10.18632/oncotarget.7423.

9)     Ca2+-Activated IK K+ Channel Blockade Radiosensitizes Glioblastoma Cells. Stegen B, Butz L, Klumpp L, Zips D, Dittmann K, Ruth P, Huber SM. Mol Cancer Res. 2015 Sep;13(9):1283-95. doi: 10.1158/1541-7786.MCR-15-0075.

10)  The ABC transporter ABCH-9C is needed for cuticle barrier construction in Locusta migratoria. Yu Z, Wang Y, Zhao X, Liu X, Ma E, Moussian B, Zhang J. Insect Biochem Mol Biol. 2017 Aug;87:90-99. doi: 10.1016/j.ibmb.2017.06.005.

11)  Double cuticle barrier in two global pests, the whitefly Trialeurodes vaporariorum and the bedbug Cimex lectularius. Wang Y, Carballo RG, Moussian B. J Exp Biol. 2017 Apr 15;220(Pt 8):1396-1399. doi: 10.1242/jeb.156679.

12)  Cuticular body hairs mediate clumping of small Camponotus floridanus larvae. Wang Y, Zuber R, Laudahn A, Berger J, Moussian B. Arthropod Struct Dev. 2017 Jan;46(1):108-115. doi: 10.1016/j.asd.2016.12.003.

13)  Inhibition if fatty acid desaturases in Drosophila melanogaster larvae blocks feeding and developmental progression. Wang Y, da Cruz TC, Pulfemuller A, Grégoire S, Ferveur JF, Moussian B. Arch Insect Biochem Physiol. 2016 May;92(1):6-23. doi: 10.1002/arch.21329.

14)  Regionalization of surface lipids in insects. Wang Y, Yu Z, Zhang J, Moussian B. Proc. R. Soc. B 2016; 283: 20152994

15)  The ABC transporter Snu and the extracellular protein Snsl cooperate in the formation of the lipid-based inward and outward barrier in the skin of Drosophila. Zuber R, Norum M, Wang Y, Oehl K, Gehring N, Accardi D, Bartozsewski S, Berger J, Flötenmeyer M, Moussian B. Eur J Cell Biol. 2018 Mar;97(2):90-101. doi: 10.1016/j.ejcb.2017.

16)  Trynity models a tube valve in the Drosophila larval airway system. Wang Y, Berger J, Moussian B.

Dev Biol. 2018 Mar 5. pii: S0012-1606(17)30917-X. doi: 10.1016/j.ydbio.2018.02.019.

17)  SK4 channels modulate Ca2+ signalling and cell cycle progression in murine breast cancer. Steudel FA, Mohr CJ, Stegen B, Nguyen HY, Barnert A, Steinle M, Beer-Hammer S, Koch P, Lo WY, Schroth W, Hoppe R, Brauch H, Ruth P, Huber SM, Lukowski R. Mol Oncol. 2017 Sep;11(9):1172-1188. doi: 10.1002/1878-0261.12087.

18)  Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide. Schroeder BO, Ehmann D, Precht JC, Castillo PA, Küchler R, Berger J, Schaller M, Stange EF, Wehkamp J. Mucosal Immunol. 2015 May;8(3):661-71. doi: 10.1038/mi.2014.100.

19)  Bacterial Periplasmic Oxidoreductases Control the Activity of Oxidized Human Antimicrobial β-Defensin 1. Wendler J, Ehmann D, Courth L, Schroeder BO, Malek NP, Wehkamp J. Infect Immun. 2018 Mar 22;86(4). pii: e00875-17. doi: 10.1128/IAI.00875-17

20)  Survival Prediction of Clear Cell Renal Cell Carcinoma Based on Gene Expression Similarity to the Proximal Tubule of the Nephron. Büttner F, Winter S, Rausch S, Reustle A, Kruck S, Junker K, Stenzl A, Agaimy A, Hartmann A, Bedke J, Schwab M, Schaeffeler E. Eur Urol. 2015 Dec;68(6):1016-20. doi: 10.1016/j.eururo.2015.05.045.

21)  Metabolic and Lipidomic Reprogramming in Renal Cell Carcinoma Subtypes Reflects Regions of Tumor Origin. Schaeffeler E, Büttner F, Reustle A, Klumpp V, Winter S, Rausch S, Fisel P, Hennenlotter J, Kruck S, Stenzl A, Wahrheit J, Sonntag D, Scharpf M, Fend F, Agaimy A, Hartmann A, Bedke J, Schwab M. Eur Urol Focus. 2018 Feb 13. pii: S2405-4569(18)30017-8. doi: 10.1016/j.euf.2018.01.016

22)  Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus. Ebner P, Rinker J, Nguyen MT, Popella P, Nega M, Luqman A, Schittek B, Di Marco M, Stevanovic S, Götz F. Infect Immun. 2016 May 24;84(6):1672-81. doi: 10.1128/IAI.00138-16.

23)  Carcinogenesis of renal cell carcinoma reflected in HLA ligands: A novel approach for synergistic peptide vaccination design. Klatt MG, Kowalewski DJ, Schuster H, Di Marco M, Hennenlotter J, Stenzl A, Rammensee HG, Stevanović S. Oncoimmunology. 2016 Jun 30;5(8):e1204504. doi: 10.1080/2162402X.2016.1204504.

24)  Characterization of the Canine MHC Class I DLA-88*50101 Peptide Binding Motif as a Prerequisite for Canine T Cell Immunotherapy. Barth SM, Schreitmüller CM, Proehl F, Oehl K, Lumpp LM, Kowalewski DJ, Di Marco M, Sturm T, Backert L, Schuster H, Stevanović S, Rammensee HG, Planz O. PLoS One. 2016 Nov 28;11(11):e0167017. doi: 10.1371/journal.pone.0167017.

25)  Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices. Di Marco M, Schuster H, Backert L, Ghosh M, Rammensee HG, Stevanović S. J Immunol. 2017 Oct 15;199(8):2639-2651. doi: 10.4049/jimmunol.1700938. 

Review articles of the PhD students during the first funding period (2014-2017)

(ICEPHA funded PhD students in bold)

1)     Reply to the Letter to the Editor by D. D'Arcangelo et al.: "Ion Channels in Brain Metastasis"-Ion Channels in Cancer Set up and Metastatic Progression Ion Channels in Brain Metastasis. Klumpp L, Sezgin EC, Eckert F, Huber SM. Int J Mol Sci. 2017 Mar 28;18(4). pii: E719. doi: 10.3390/ijms18040719.

2)     Ion Channels in Brain Metastasis. Klumpp L, Sezgin EC, Eckert F, Huber SM. Int J Mol Sci. 2016 Sep 8;17(9). pii: E1513. doi: 10.3390/ijms17091513.

3)     Role of ion channels in ionizing radiation-induced cell death. Huber SM, Butz L, Stegen B, Klumpp L, Klumpp D, Eckert F. Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2657-64. doi: 10.1016/j.bbamem.2014.11.004.

4)     K+ channel signaling in irradiated tumor cells. Stegen B, Klumpp L, Misovic M, Edalat L, Eckert M, Klumpp D, Ruth P, Huber SM. Eur Biophys J. 2016 Oct;45(7):585-598. Epub 2016 May 10.

5)     Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors. Neul C, Schaeffeler E, Sparreboom A, Laufer S, Schwab M, Nies AT. Trends Pharmacol Sci. 2016 Nov;37(11):904-932. doi: 10.1016/j.tips.2016.08.003.

6)     Identification of Immunogenic Epitopes by MS/MS. Di Marco M, Peper JK, Rammensee HG. Cancer J. 2017 Mar/Apr;23(2):102-107. doi: 10.1097/PPO.0000000000000252.