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Overview of the Projects

 

 

Project

PIs

Title




1

Stefan &

Burk

The role of pregnane X receptor-dependent lipid metabolism in the pathophysiology of non-alcoholic fatty liver disease and its complications

2

Hailfinger, Schulze-Osthoff &

Schäffeler, Schwab

Regulation of the CD147-MCT lactate transporter complex by the novel protein SMIM11 in cancerogenesis

3

Huber, Zips &

Winter, Thomas

The SDF-1/CXCR4 axis in glioblastoma as biomarker and potential therapeutic target for radiation therapy

4

Laufer &

Nies

Identification of transporters for drug disposition of the novel MAPK14 inhibitor Skepinone-L and ist regioisomers in combination with multikinase inhibitor sorafenib in human hepatocellular carcinoma

5

Moussian &

Schwab, Nies

The model of the fruit fly Drosophila melanogaster as a novel and highly innovative test system for human membrane transporters in anti-cancer drug development

6

Ruth, Lukowski &

Brauch, Schroth

Genetic variants in KCa channel multiprotein-complexes as predictive factors for breast cancer risk and treatment outcome

7

Wehkamp &

Stange

Combined histone deacetylase inhibition and E.coli Nissle 1917 treatment as novel therapy in colon carcinoma

8

Stevanovic, Bedke &

Schwab, Schäffeler

Elucidation of underlying genomic, epigenomic and metabolomic factors contributing to the expression of candidate targets identified by HLA ligandome analysis in ccRCC

 

 

 

Z1

Nürnberg

ICEPHA mouse clinic

Z2

Lukowski, Laufer

Administrative and central tasks