Home » Core Members » University of Tübingen » Pharmacology and Toxicology, Institute of Pharmacy » Publications

Selected Publications

  

Klumpp D, Frank SC, Klumpp L, Sezgin EC, Eckert M, Edalat L, Bastmeyer M, Zips D, Ruth P, Huber SM. TRPM8 is required for survival and radioresistance of glioblastoma cells. Oncotarget. 2017 Sep 30;8(56):95896-95913. doi:10.18632/oncotarget.21436.

 

Frankenreiter S, Bednarczyk P, Kniess A, Bork NI, Straubinger J, Koprowski P, Wrzosek A, Mohr E, Logan A, Murphy MP, Gawaz M, Krieg T, Szewczyk A, Nikolaev VO, Ruth P, Lukowski R. cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels. Circulation. 2017 Dec 12;136(24):2337-2355.

 

Steudel FA, Mohr CJ, Stegen B, Nguyen HY, Barnert A, Steinle M, Beer-Hammer S, Koch P, Lo WY, Schroth W, Hoppe R, Brauch H, Ruth P, Huber SM, Lukowski R. SK4 channels modulate Ca(2+) signalling and cell cycle progression in murine breast cancer. Mol Oncol. 2017 Sep;11(9):1172-1188. doi: 10.1002/1878-0261.12087.

 

Illison J, Tian L, McClafferty H, Werno M, Chamberlain LH, Leiss V, SassmannA, Offermanns S, Ruth P, Shipston MJ, Lukowski R. Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels. Diabetes. 2016 Dec;65(12):3621-3635.

 

Edalat L, Stegen B, Klumpp L, Haehl E, Schilbach K, Lukowski R, Kühnle M, Bernhardt G, Buschauer A, Zips D, Ruth P, Huber SM. BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells. Oncotarget. 2016 Mar 22;7(12):14259-78. doi: 10.18632/oncotarget.7423.

 

Fleming MR, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK. Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex. Cell Rep. 2016 Aug 30;16(9):2281-8. doi:10.1016/j.celrep.2016.07.024. Epub 2016 Aug 18.

 

Stegen B, Butz L, Klumpp L, Zips D, Dittmann K, Ruth P, Huber SM. Ca2+-Activated IK K+ Channel Blockade Radiosensitizes Glioblastoma Cells. Mol Cancer Res. 2015 Sep;13(9):1283-95. doi: 10.1158/1541-7786.MCR-15-0075.

 

Zhou XB, Feng YX, Sun Q, Lukowski R, Qiu Y, Spiger K, Li Z, Ruth P, Korth M, Skolnik EY, Borggrefe M, Dobrev D, Wieland T. Nucleoside diphosphate kinase B-activated intermediate conductance potassium channels are critical for neointima formation in mouse carotid arteries. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1852-61. doi: 10.1161/ATVBAHA.115.305881.

 

Nies AT, Schaeffeler E, van der Kuip H, Cascorbi I, Bruhn O, Kneba M, Pott C, Hofmann U, Volk C, Hu S, Baker SD, Sparreboom A, Ruth P, Koepsell H, Schwab M. Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1). Clin Cancer Res. 2014 Feb 15;20(4):985-94. doi: 10.1158/1078-0432.CCR-13-1999. Epub 2013 Dec 18.

 

Müller C, Más Gómez N, Ruth P, Strauss O. CaV1.3 L-type channels, maxiK Ca(2+)-dependent K(+) channels and bestrophin-1 regulate rhythmic photoreceptor outer segment phagocytosis by retinal pigment epithelial cells. Cell Signal. 2014 May;26(5):968-78. doi: 10.1016/j.cellsig.2013.12.021.

 

Duncan PJ, Sengul S, Tabak J, Ruth P, Bertram R, Shipston MJ. Large conductance Ca(2+) -activated K(+) channels (BK) promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs. J Physiol. 2014 Dec 24. doi: 10.1113/jphysiol.2014.284471.

 

Schneider H, Schubert KM, Blodow S, Kreutz CP, Erdogmus S, Wiedenmann M, Qiu J, Fey T, Ruth P, Lubomirov LT, Pfitzer G, Mederos Y Schnitzler M, Hardie DG, Gudermann T, Pohl U. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle. Hypertension. 2015 Jul;66(1):108-16. doi: 10.1161/HYPERTENSIONAHA.115.05514..

 

Hosseinzadeh Z, Almilaji A, Honisch S, Pakladok T, Liu G, Bhavsar SK, Ruth P, Shumilina E, Lang F. Upregulation of the large conductance voltage- and Ca2+-activated K+ channels by Janus kinase 2. Am J Physiol Cell Physiol. 2014 Jun 1;306(11):C1041-9. doi: 10.1152/ajpcell.00209.2013.

 

Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignano M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A. BKCa channels expressed in sensory neurons modulate inflammatory pain in mice. Pain. 2014 Mar;155(3):556-65. doi: 10.1016/j.pain.2013.12.005.

 

Chen L, Bi D, Tian L, McClafferty H, Steeb F, Ruth P, Knaus HG, Shipston MJ. Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants. J Biol Chem. 2013 May 3;288(18):13136-44. doi: 10.1074/jbc.M113.461830.

 

Zhou X, Wulfsen I, Korth M, McClafferty H, Lukowski R, Shipston MJ, Ruth P, Dobrev D, Wieland T. Palmitoylation and membrane association of the stress axis regulated insert (STREX) controls BK channel regulation by protein kinase C. J Biol Chem. 2012 Sep 14;287(38):32161-71. doi: 10.1074/jbc.M112.386359.

 

Kurt S, Sausbier M, Rüttiger L, Brandt N, Moeller CK, Kindler J, Sausbier U, Zimmermann U, van Straaten H, Neuhuber W, Engel J, Knipper M, Ruth P, Schulze H. Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing. FASEB J. 2012 Sep;26(9):3834-43. doi: 10.1096/fj.11-200535.

 

Tanimoto N, Sothilingam V, Euler T, Ruth P, Seeliger MW, Schubert T. BK channels mediate pathway-specific modulation of visual signals in the in vivo mouse retina. J Neurosci. 2012 Apr 4;32(14):4861-6. doi:10.1523/JNEUROSCI.4654-11.2012.

 

Tian L, McClafferty H, Knaus HG, Ruth P, Shipston MJ. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. J Biol Chem. 2012 Apr 27;287(18):14718-25. doi:10.1074/ jbc.M111.335547.

 

Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L. cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med. 2012 Jan 22;18(2):252-9. doi: 10.1038/nm.2634.