Home » Core Members » Medical Faculty of the University of Tübingen » Experimental Pharmacology and Toxicology, Medical Faculty » Publications

Selected Publications

 

Dembla S., Behrendt M., Mohr F., Goecke C., Sondermann J., Schneider F.M., Stab J., Enzeroth R., Leitner M.G., Nuñez-Badinez P., Schwenk J., Nürnberg B., Cohen A., Philipp S., Greffrath W., Bünemann M., Oliver D., Zakharian E., Schmidt M., Oberwinkler J. (2017): Antinociceptive action of peripheral µ-opioid receptors by Gbg protein-mediated inhibition of TRPM3 channels. eLife 2017;6:e26280 doi: 10.7554/eLife26280

Mauriac S.A., Hien E.Y., Bird J., DosSantos Carvalho S., Peyroutou R., Lee S.C., Moreau M.M., Blanc J.-M., Geyser A., Medina C., Thoumine O., BeerHammer S., Friedman T., Rüttiger L., Forge A., Nürnberg B., Sans N., Montcouquiol M. (2017): Defective Gpsm2/Gai3 signaling disrupts stereocilia development and growth cone actin dynamics in Chudley McCullough syndrome. Nature Commun. 2017 Apr 7; 8:14907. doi: 10.1038/ncomms14907

Bucher K., Schmitt F., Autenrieth S., Dillmann I., Nürnberg B., Schenke-Layland K., Beer-Hammer S. (2015): Ly6G antibodies determine macrophage phagocytosis of neutrophils and alter the retrieval of neutrophils in mice. J. Leukoc. Biol. 98, 365-372

Mahiny A.J., Dewerth A., Mays L.E., Alkhaled M., Mothes B., Malaeksefat E., Loretz B., Rottenberger J., Brosch D.M., Reautschnig P., Surapolchai P., Zeyer F., Schams A., Carevic M., Bakele M., Griese M., Schwab M., Nürnberg B., Beer-Hammer S., Handgretinger R., Hartl D., Lehr C.-M., Kormann M.S.D. (2015): In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency. Nat. Biotechnol. 33, 584-586

Devanathan V., Hagedorn I., Köhler D., Pexa K., Cherpokova D., Kraft P., Singh M., Rosenberger P., Stoll G., Birnbaumer L., Piekorz R., Beer-Hammer S., Nieswandt B., Nürnberg B. (2015): Platelet Gai2 is an essential mediator of thrombo-inflammatory organ damage in mice. Proc. Natl. Acad. Sci. USA 112, 6491-6496

Vadas O., Dbouk H.A., Shymanets A., Perisic O., Burke J.E., Khalil B.D., Ohashi M., Harteneck C., Nürnberg B., Backer J.M., Williams R.L. (2013): Molecular determinants of PI3Kg-mediated activation downstream of GPCRs. Proc. Natl. Acad.  Sci. USA 110, 18862-18867

Shymanets A., Prajwal, Bucher K., Beer-Hammer S., Harteneck C., Nürnberg B. (2013): p87 and p101 subunits are distinct regulators determining class IB PI3K specificity. J. Biol. Chem. 288, 31059-31068

Ezan J., Lasvaux L., Gezer A., Novakovic A., May-Simera H., Belotti E., Lhoumeau A.-C., Birnbaumer L., Beer-Hammer S., Borg J.-P., LeBivic A., Nürnberg B., Sans N., Montcouquiol M. (2013): Primary cilium migration depends on G-protein signaling control of subapical cytoskeleton. Nat. Cell Biol. 15, 1107-1115

Mays L.E., Ammon-Treiber S., Mothes B., Alkhaled M., Rottenberger J., Müller-Hermelink E.S., Grimm M., Mezger M., Beer-Hammer S., von Stebut E., Rieber N., Nürnberg B., Schwab M., Handgretinger R., Idzko M., Hartl D., Kormann M.S.D. (2013): Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism. J. Clin. Invest. 123, 1216-1228

Wiege K., Ali S.R., Gewecke B., Novakovic A., Konrad F.M., Pexa K., Beer-Hammer S., Reutershan J., Piekorz R.P., Schmidt R.E., Nürnberg B., Gessner J.E. (2013): Gαi2 is the essential Gαi protein in immune complex-induced lung disease. J. Immunol. 190, 324-333

Plummer N.W., Spicher K., Malphurs J., Akiyama H., Abramowitz J., Nürnberg B., Birnbaumer L. (2012): Development of the mammalian axial skeleton requires signaling through the Gai subfamily of heterotrimeric G proteins. Proc. Natl. Acad. Sci. USA 109, 21366-21371

Dbouk H.A., Vadas O., Shymanets A., Burke J.E., Salamon R.S., Khalil B.D., Barett M.O., Waldo G.L., Surve C., Hsueh C., Perisic O., Harteneck C., Shepherd P.R., Harden T.K., Smrcka A.V., Taussig R., Bresnick A.R., Nürnberg B., Williams R.L., Backer J.M. (2012): G Protein-coupled receptor-mediated activation of p110b by Gbg is required for cell transformation and invasiveness. Sci. Signal. 5, ra89

Wiege K., Duc D.L., Syed S.N., Ali S.R., Novakovic A., Beer-Hammer S., Piekorz R.P., Schmidt R.E., Nürnberg B., Gessner J.E. (2012): Defective macrophage migration in Gαi2- but not Gαi3-deficient mice. J. Immunol. 189, 980-987

Schmidt S., Schneider L., Essmann F., Cirstea I.C., Kuck F., Kletke A, Jänicke R.U., Wiek C., Hanenberg H., Ahmadian M.R., Schulze-Osthoff K., Nürnberg B., Piekorz R.P. (2010): The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29, 6184-6192

Kurig B., Shymanets A., Bohnacker T., Prajwal, Brock C., Ahmadian M.R., Schaefer M., Gohla A., Harteneck C., Wymann M.P., Jeanclos E., Nürnberg B. (2009): Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ. Proc. Natl. Acad.  Sci. USA 106, 20312-20317

Schneider L., Essmann F., Kletke A., Rio P., Hanenberg H., Schulze-Osthoff K., Nürnberg B., Piekorz R.P. (2008): TACC3 depletion sensitizes cells to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 27, 116-125

Pivarcsi A., Müller A., Hippe A., Rieker J., van Lierop A., Steinhoff M., Seeliger S., Kubitza R., Pippirs U., Meller S., Gerber A.P., Liersch R., Buenemann E., Sonkoly E., Wiesner U., Hoffmann T.K., Schneider L., Piekorz R.P., Enderlain E., Reifenberger J., Rohr U.-P., Haas R., Boukamp P., Haase I., Nürnberg B., Ruzicka T., Zlotnik A., Homey B. (2007): Tumor immune escape by the loss of homeostatic chemokine expression. Proc. Natl. Acad.  Sci. USA 104, 19055-19060

Gohla A., Klement K., Piekorz R.P., Pexa K., vom Dahl S., Spicher K., Dreval V., Häussinger D., Birnbaumer L., Nürnberg B. (2007): An obligatory requirement for the heterotrimeric G protein Gi3 in the anti-autophagic action of insulin in the liver. Proc. Natl. Acad.  Sci. USA 104, 3003-3008

Voigt P., Brock C., Nürnberg B., Schaefer M. (2005): Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase g. J. Biol. Chem. 280, 5121-5127

Skokowa J., Ali S.R., Felda O., Kumar V., Konrad S., Shushakova N., Schmidt R.E., Piekorz R.P., Nürnberg B., Spicher K., Birnbaumer L., Zwirner J., Claassens J.W.C., Verbeek J.S., van Rooijen N., Köhl J., Gessner J.E. (2005): Macrophages induce the inflammatory response in the pulmonary Arthus reaction through Gαi2 activation that controls C5aR and Fc receptor cooperation. J. Immunol. 174, 3041-3050

Viard P., Butcher A., Halet G., Davies A., Nürnberg B., Heblich F., Dolphin A.C. (2004): PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nature Neurosci. 7, 939-946

Brock C., Schaefer M., Reusch P., Czupalla C., Michalke M., Spicher K., Schultz G., Nürnberg B. (2003): Roles of Gbg in membrane recruitment and activation of p110g/p101 phosphoinositide 3-kinase g. J. Cell Biol. 160, 89-99

Czupalla C., Culo M., Müller E.C., Brock C., Reusch H.P., Spicher K., Krause E., Nürnberg B. (2003): Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms b and g. J. Biol. Chem. 278, 11536-11545

Breitweg-Lehmann E., Czupalla C., Storm R., Kudlacek O., Schunack W., Freissmuth M., Nürnberg B. (2002): Activation and inhibition of G proteins by lipoamines. Mol. Pharmacol. 61, 628-636

Scholze A., Plant T., Dolphin A.C., Nürnberg B. (2001): Functional expression and characterization of a voltage-gated Cav1.3 (a1D) calcium channel subunit from an insulin-secreting cell line. Mol. Endocrinol. 15, 1211-1221

Macrez N., Mironneau C., Carricaburu V., Quignar J.F., Babich A., Czupalla C., Nürnberg B., Mironneau J. (2001): Phosphoinositide-3-kinase isoforms selectively couple receptors to vascular L-type Ca2+ channels. Circulation Res. 89, 692-699

Exner T., Jensen O.N., Kleuss C., Mann M., Nürnberg B. (1999): Posttranslational modification of Gao1 generates Gao3, an abundant G protein in brain. Proc. Natl. Acad. Sci. USA 96, 1327-1332

Viard P., Exner T., Maier U., Mironneau J., Nürnberg B., Macrez N. (1999): G protein bg dimers stimulate vascular L-type Ca2+ channels via phosphoinositide-3-kinase. FASEB J. 13, 685-694

Maier U., Babich A., Nürnberg B. (1999): Roles of non-catalytic subunits in Gbg-induced activation of class I phosphoinositide 3-kinase isoforms b and g. J. Biol. Chem. 274, 29311-29317

Ahnert-Hilger G., Nürnberg B., Exner T., Schäfer T., Jahn R. (1998): The heterotrimeric G protein Gao2 regulates catecholamine uptake by secretory vesicles. EMBO J. 17, 406-413

Leopoldt D., Hanck T., Exner T., Maier U., Wetzker R., Nürnberg B. (1998): Gbg stimulates PI3Kg by direct interaction with two domains of the catalytic p110 subunit. J. Biol. Chem. 273, 7024-7029

Obukhov A., Harteneck C., Zobel A., Harhammer R., Kalkbrenner F., Leopoldt D., Lückhoff A., Nürn­berg B., Schultz G. (1996): Direct activation of trpl cation channels by Ga11 subunits. EMBO J. 15, 5833-5838

Stoyanov B., Volinia S., Hanck T., Rubio I., Loubtchenkov M., Malek D., Stoyanova S., Vanhaesebroeck B., Dhand R., Nürnberg B., Gierschik P., Seedorf K., Hsuan J.J., Waterfield M.D., Wetzker R. (1995): Cloning and characterization of a G protein-activated human phosphatidylinositol-3 kinase. Science 269, 690-693

Nürnberg B., Köhler G., Brune K. (1991): Pharmacokinetics of diflunisal in patients. Clin. Pharmacokinet. 20, 81-89

Beck W.S., Schneider H.T., Dietzel K., Nürnberg B., Brune K. (1990): Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats: physicochemical and biochemical factors involved. Arch. Toxicol. 64, 210-217

Nürnberg B., Szelenyi I., Schneider H.T., Brune K. (1990): Diflunisal disposition: role of gastric absorption in the development of mucosal damage and anti-inflammatory potency in rodents. Drug Metab. Dispos. 18, 937-942

Schneider H.T., Nürnberg B., Dietzel K., Brune K., (1990): Biliary secretion of anti-rheumatic drugs in man. Br. J. Clin. Pharmac. 29, 127-131

Nürnberg B., Koehnke R., Solsky M., Hoffman J., Furst D.E. (1990): Biliary elimination of low dose methotrexate in man. Arthritis Rheum. 33, 898-902