Selected Publications
Dembla S., Behrendt M., Mohr F., Goecke C., Sondermann J., Schneider F.M., Stab J., Enzeroth R., Leitner M.G., Nuñez-Badinez P., Schwenk J., Nürnberg B., Cohen A., Philipp S., Greffrath W., Bünemann M., Oliver D., Zakharian E., Schmidt M., Oberwinkler J. (2017): Antinociceptive action of peripheral µ-opioid receptors by Gbg protein-mediated inhibition of TRPM3 channels. eLife 2017;6:e26280 doi: 10.7554/eLife26280
Mauriac S.A., Hien E.Y., Bird J., Dos‐Santos Carvalho S., Peyroutou R., Lee S.C., Moreau M.M., Blanc J.-M., Geyser A., Medina C., Thoumine O., Beer‐Hammer S., Friedman T., Rüttiger L., Forge A., Nürnberg B., Sans N., Montcouquiol M. (2017): Defective Gpsm2/Gai3 signaling disrupts stereocilia development and growth cone actin dynamics in Chudley McCullough syndrome. Nature Commun. 2017 Apr 7; 8:14907. doi: 10.1038/ncomms14907
Bucher K., Schmitt F., Autenrieth S., Dillmann I., Nürnberg B., Schenke-Layland K., Beer-Hammer S. (2015): Ly6G antibodies determine macrophage phagocytosis of neutrophils and alter the retrieval of neutrophils in mice. J. Leukoc. Biol. 98, 365-372
Mahiny A.J., Dewerth A., Mays L.E., Alkhaled M., Mothes B., Malaeksefat E., Loretz B., Rottenberger J., Brosch D.M., Reautschnig P., Surapolchai P., Zeyer F., Schams A., Carevic M., Bakele M., Griese M., Schwab M., Nürnberg B., Beer-Hammer S., Handgretinger R., Hartl D., Lehr C.-M., Kormann M.S.D. (2015): In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency. Nat. Biotechnol. 33, 584-586
Devanathan V., Hagedorn I., Köhler D., Pexa K., Cherpokova D., Kraft P., Singh M., Rosenberger P., Stoll G., Birnbaumer L., Piekorz R., Beer-Hammer S., Nieswandt B., Nürnberg B. (2015): Platelet Gai2 is an essential mediator of thrombo-inflammatory organ damage in mice. Proc. Natl. Acad. Sci. USA 112, 6491-6496
Vadas O., Dbouk H.A., Shymanets A., Perisic O., Burke J.E., Khalil B.D., Ohashi M., Harteneck C., Nürnberg B., Backer J.M., Williams R.L. (2013): Molecular determinants of PI3Kg-mediated activation downstream of GPCRs. Proc. Natl. Acad. Sci. USA 110, 18862-18867
Shymanets A., Prajwal, Bucher K., Beer-Hammer S., Harteneck C., Nürnberg B. (2013): p87 and p101 subunits are distinct regulators determining class IB PI3K specificity. J. Biol. Chem. 288, 31059-31068
Ezan J., Lasvaux L., Gezer A., Novakovic A., May-Simera H., Belotti E., Lhoumeau A.-C., Birnbaumer L., Beer-Hammer S., Borg J.-P., LeBivic A., Nürnberg B., Sans N., Montcouquiol M. (2013): Primary cilium migration depends on G-protein signaling control of subapical cytoskeleton. Nat. Cell Biol. 15, 1107-1115
Mays L.E., Ammon-Treiber S., Mothes B., Alkhaled M., Rottenberger J., Müller-Hermelink E.S., Grimm M., Mezger M., Beer-Hammer S., von Stebut E., Rieber N., Nürnberg B., Schwab M., Handgretinger R., Idzko M., Hartl D., Kormann M.S.D. (2013): Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism. J. Clin. Invest. 123, 1216-1228
Wiege K., Ali S.R., Gewecke B., Novakovic A., Konrad F.M., Pexa K., Beer-Hammer S., Reutershan J., Piekorz R.P., Schmidt R.E., Nürnberg B., Gessner J.E. (2013): Gαi2 is the essential Gαi protein in immune complex-induced lung disease. J. Immunol. 190, 324-333
Plummer N.W., Spicher K., Malphurs J., Akiyama H., Abramowitz J., Nürnberg B., Birnbaumer L. (2012): Development of the mammalian axial skeleton requires signaling through the Gai subfamily of heterotrimeric G proteins. Proc. Natl. Acad. Sci. USA 109, 21366-21371
Dbouk H.A., Vadas O., Shymanets A., Burke J.E., Salamon R.S., Khalil B.D., Barett M.O., Waldo G.L., Surve C., Hsueh C., Perisic O., Harteneck C., Shepherd P.R., Harden T.K., Smrcka A.V., Taussig R., Bresnick A.R., Nürnberg B., Williams R.L., Backer J.M. (2012): G Protein-coupled receptor-mediated activation of p110b by Gbg is required for cell transformation and invasiveness. Sci. Signal. 5, ra89
Wiege K., Duc D.L., Syed S.N., Ali S.R., Novakovic A., Beer-Hammer S., Piekorz R.P., Schmidt R.E., Nürnberg B., Gessner J.E. (2012): Defective macrophage migration in Gαi2- but not Gαi3-deficient mice. J. Immunol. 189, 980-987
Schmidt S., Schneider L., Essmann F., Cirstea I.C., Kuck F., Kletke A, Jänicke R.U., Wiek C., Hanenberg H., Ahmadian M.R., Schulze-Osthoff K., Nürnberg B., Piekorz R.P. (2010): The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29, 6184-6192
Kurig B., Shymanets A., Bohnacker T., Prajwal, Brock C., Ahmadian M.R., Schaefer M., Gohla A., Harteneck C., Wymann M.P., Jeanclos E., Nürnberg B. (2009): Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ. Proc. Natl. Acad. Sci. USA 106, 20312-20317
Schneider L., Essmann F., Kletke A., Rio P., Hanenberg H., Schulze-Osthoff K., Nürnberg B., Piekorz R.P. (2008): TACC3 depletion sensitizes cells to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene 27, 116-125
Pivarcsi A., Müller A., Hippe A., Rieker J., van Lierop A., Steinhoff M., Seeliger S., Kubitza R., Pippirs U., Meller S., Gerber A.P., Liersch R., Buenemann E., Sonkoly E., Wiesner U., Hoffmann T.K., Schneider L., Piekorz R.P., Enderlain E., Reifenberger J., Rohr U.-P., Haas R., Boukamp P., Haase I., Nürnberg B., Ruzicka T., Zlotnik A., Homey B. (2007): Tumor immune escape by the loss of homeostatic chemokine expression. Proc. Natl. Acad. Sci. USA 104, 19055-19060
Gohla A., Klement K., Piekorz R.P., Pexa K., vom Dahl S., Spicher K., Dreval V., Häussinger D., Birnbaumer L., Nürnberg B. (2007): An obligatory requirement for the heterotrimeric G protein Gi3 in the anti-autophagic action of insulin in the liver. Proc. Natl. Acad. Sci. USA 104, 3003-3008
Voigt P., Brock C., Nürnberg B., Schaefer M. (2005): Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase g. J. Biol. Chem. 280, 5121-5127
Skokowa J., Ali S.R., Felda O., Kumar V., Konrad S., Shushakova N., Schmidt R.E., Piekorz R.P., Nürnberg B., Spicher K., Birnbaumer L., Zwirner J., Claassens J.W.C., Verbeek J.S., van Rooijen N., Köhl J., Gessner J.E. (2005): Macrophages induce the inflammatory response in the pulmonary Arthus reaction through Gαi2 activation that controls C5aR and Fc receptor cooperation. J. Immunol. 174, 3041-3050
Viard P., Butcher A., Halet G., Davies A., Nürnberg B., Heblich F., Dolphin A.C. (2004): PI3K promotes voltage-dependent calcium channel trafficking to the plasma membrane. Nature Neurosci. 7, 939-946
Brock C., Schaefer M., Reusch P., Czupalla C., Michalke M., Spicher K., Schultz G., Nürnberg B. (2003): Roles of Gbg in membrane recruitment and activation of p110g/p101 phosphoinositide 3-kinase g. J. Cell Biol. 160, 89-99
Czupalla C., Culo M., Müller E.C., Brock C., Reusch H.P., Spicher K., Krause E., Nürnberg B. (2003): Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms b and g. J. Biol. Chem. 278, 11536-11545
Breitweg-Lehmann E., Czupalla C., Storm R., Kudlacek O., Schunack W., Freissmuth M., Nürnberg B. (2002): Activation and inhibition of G proteins by lipoamines. Mol. Pharmacol. 61, 628-636
Scholze A., Plant T., Dolphin A.C., Nürnberg B. (2001): Functional expression and characterization of a voltage-gated Cav1.3 (a1D) calcium channel subunit from an insulin-secreting cell line. Mol. Endocrinol. 15, 1211-1221
Macrez N., Mironneau C., Carricaburu V., Quignar J.F., Babich A., Czupalla C., Nürnberg B., Mironneau J. (2001): Phosphoinositide-3-kinase isoforms selectively couple receptors to vascular L-type Ca2+ channels. Circulation Res. 89, 692-699
Exner T., Jensen O.N., Kleuss C., Mann M., Nürnberg B. (1999): Posttranslational modification of Gao1 generates Gao3, an abundant G protein in brain. Proc. Natl. Acad. Sci. USA 96, 1327-1332
Viard P., Exner T., Maier U., Mironneau J., Nürnberg B., Macrez N. (1999): G protein bg dimers stimulate vascular L-type Ca2+ channels via phosphoinositide-3-kinase. FASEB J. 13, 685-694
Maier U., Babich A., Nürnberg B. (1999): Roles of non-catalytic subunits in Gbg-induced activation of class I phosphoinositide 3-kinase isoforms b and g. J. Biol. Chem. 274, 29311-29317
Ahnert-Hilger G., Nürnberg B., Exner T., Schäfer T., Jahn R. (1998): The heterotrimeric G protein Gao2 regulates catecholamine uptake by secretory vesicles. EMBO J. 17, 406-413
Leopoldt D., Hanck T., Exner T., Maier U., Wetzker R., Nürnberg B. (1998): Gbg stimulates PI3Kg by direct interaction with two domains of the catalytic p110 subunit. J. Biol. Chem. 273, 7024-7029
Obukhov A., Harteneck C., Zobel A., Harhammer R., Kalkbrenner F., Leopoldt D., Lückhoff A., Nürnberg B., Schultz G. (1996): Direct activation of trpl cation channels by Ga11 subunits. EMBO J. 15, 5833-5838
Stoyanov B., Volinia S., Hanck T., Rubio I., Loubtchenkov M., Malek D., Stoyanova S., Vanhaesebroeck B., Dhand R., Nürnberg B., Gierschik P., Seedorf K., Hsuan J.J., Waterfield M.D., Wetzker R. (1995): Cloning and characterization of a G protein-activated human phosphatidylinositol-3 kinase. Science 269, 690-693
Nürnberg B., Köhler G., Brune K. (1991): Pharmacokinetics of diflunisal in patients. Clin. Pharmacokinet. 20, 81-89
Beck W.S., Schneider H.T., Dietzel K., Nürnberg B., Brune K. (1990): Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats: physicochemical and biochemical factors involved. Arch. Toxicol. 64, 210-217
Nürnberg B., Szelenyi I., Schneider H.T., Brune K. (1990): Diflunisal disposition: role of gastric absorption in the development of mucosal damage and anti-inflammatory potency in rodents. Drug Metab. Dispos. 18, 937-942
Schneider H.T., Nürnberg B., Dietzel K., Brune K., (1990): Biliary secretion of anti-rheumatic drugs in man. Br. J. Clin. Pharmac. 29, 127-131
Nürnberg B., Koehnke R., Solsky M., Hoffman J., Furst D.E. (1990): Biliary elimination of low dose methotrexate in man. Arthritis Rheum. 33, 898-902